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Designer molecule lowers HIV levels: trial results

This meant the designer molecule dubbed 3BNC117 may be best used in combination with other drugs, said the team — while highlighting the promise of a new, immunotherapy-based approach to fighting HIV. “This represents potentially a new class of drugs with activity against HIV,” study co-author Marina Caskey of New York's Rockefeller University told AFP. So-called monoclonal antibodies like 3BNC117 which are cloned from a single parent immune cell, hold the promise of actually killing HIV-infected cells. The new agent, cloned from a cell taken from an HIV-positive person, was given to 12 uninfected volunteers and 17 infected with HIV.

Futures point to flat open, major indexes at records

NEW YORK (Reuters) – U.S. stock index futures pointed to a quiet open on Tuesday, the first trading session after the S&P 500 closed at a record high, although investors continued to watch the uncertainty over a Greek debt deal and a fragile Ukraine truce.

Crowds attack Ebola facility, health workers in Guinea

Crowds destroyed an Ebola facility and attacked health workers in central Guinea on rumours that the Red Cross was planning to disinfect a school, a government spokesman said on Saturday. Red Cross teams in Guinea have been attacked on average 10 times a month over the past year, the organisation said this week, warning that the violence was hampering efforts to contain the disease. During the incident on Friday in the town of Faranah, around 400 km (250 miles) east of the capital Conakry, angry residents attacked an Ebola transit centre and set ablaze a vehicle belonging to medical charity Medecins Sans Frontieres. A Red Cross burial team was also targeted and forced to flee, said Fodé Tass Sylla, spokesman for the government campaign against the disease.

Hormone drugs boost ovarian cancer risk by 40%

Menopausal women who take hormone replacement therapy (HRT) boost the risk of ovarian cancer by 40 percent, even if they take the treatment only for a few years, a study said Friday. The probe marks the widest-ever analysis of the risk of ovarian cancer from HRT, a treatment whose use declined when its safety was questioned a dozen years ago. Researchers publishing in The Lancet carried out an overview of 52 published studies, covering nearly 21,500 women in North America, Europe and Australia who had been diagnosed with ovarian cancer. “For women who take HRT for five years from around age 50, there will be about one extra ovarian cancer for every 1,000 users, and one extra ovarian cancer death for every 1,700 users,” said Richard Peto, a University of Oxford professor who co-authored the study.

Three wounded in shooting at Pittsburgh area shopping mall

By Daniel Kelley PHILADELPHIA (Reuters) – A gunman wounded three people at a Macy’s department store in a shopping center outside Pittsburgh on Saturday in what police said was a shooting that targeted one of the victims. “We believe that one of those three people shot was a targeted individual,” said Monroeville Police Chief Doug Cole of the incident at the Monroeville Mall outside Pittsburgh. Andy Sherman, head of the Allegheny County Detective Division, said surveillance videos could help identify the gunman. The victims were taken to Forbes Hospital in Monroeville, about 12 miles (20 km) east of Pittsburgh, where two were in critical condition and one was in fair condition, according to Dan Laurent, a hospital spokesman.